Vitamin D levels and vitamin D receptor genetic variants in Egyptian cardiovascular disease patients with and without diabetes

Abstract Background 25-Hydroxyvitamin D (Vit.D) levels associated with cardiovascular disease (CVD) may vary according to genetic variants in the vitamin receptor (VDR) gene. However, existing results are not conclusive Egyptian population, where diabetes mellitus is a common CVD risk factor. The purpose of study was evaluate role VDR polymorphism patients by studying association rs2228570 ( FokI ) and rs1544410 BsmI single nucleotide polymorphisms (SNPs) gene serum Vit.D several factors without mellitus. We studied genotypes for SNPs 382 (120 diabetes, 124 69 diabetic healthy individuals). also determined Vit.D, insulin, lipids, fasting blood glucose (FBG), body mass index (BMI). Results distribution allelic frequencies significant (p < 0.001). level significantly lower compared those Moreover, there between selected BMI, FBG, insulin or diabetes. Conclusion These suggest that be potential diagnostic biomarkers susceptibility.